Association of vitamin D deficiency with coronary artery disease in Mexican population: Genetics of atherosclerotic disease study

  • López-Bautista F
  • Posadas-Romero C
  • Cardoso-Saldaña G
  • et al.
N/ACitations
Citations of this article
24Readers
Mendeley users who have this article in their library.

Abstract

© 2017, Academia Nacional de Medicina. All rights reserved. Objective: To investigate the independent association between vitamin D deficiency (VDD) and coronary artery disease (CAD) in Mexican adult population. Method: Matched case-control study. Data cardiovascular on risk factors, medication use, physical activity, alcohol use, smoking and vitamin D consumption were obtained. Biochemical variables, anthropometric and blood pressure were measured. 25(OH)D was quantified by chemiluminescence. Results: We studied 250 patients with established CAD and 250 age-gender-body mass index (BMI) matched control subjects, with a mean age of 53 ± 6.1 years and BMI of 28 ± 3.5 kg/m 2 . Deficiency of 25(OH)D was significantly higher in the control group (21.2 vs. 16%). Multiple logistic regression analysis did not show association between VDD and CAD (OR: 1.37 [0.08-23.2]). Multiple linear regression analysis also showed that statin use (b = 2.2; p = 0.004) and no alcohol use (b = −1.8; p = 0.03) significantly increased 25(OH)D levels. Conclusions: No independent association between VDD and the presence of coronary artery disease was found in Mexican adult population. The results suggest that treatment with statins and absence of alcohol consumption, might be the explanation for the higher concentrations of 25(OH)D observed in patients with CAD.

Cite

CITATION STYLE

APA

López-Bautista, F., Posadas-Romero, C., Cardoso-Saldaña, G., Juárez-Rojas, J. G., Medina-Urrutia, A. X., Pérez-Hernández, N., … Posadas-Sánchez, R. (2023). Association of vitamin D deficiency with coronary artery disease in Mexican population: Genetics of atherosclerotic disease study. Gaceta Médica de México, 153(5). https://doi.org/10.24875/gmm.m18000040

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free