Effects of high salt stress on secondary metabolite production in the marine-derived fungus Spicaria elegans

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Abstract

To obtain structurally novel and bioactive natural compounds from marine-derived microorganisms, the effect of high salt stress on secondary metabolite production in the marine-derived fungal strain, Spicaria elegans KLA-03, was investigated. The organism, which was isolated from marine sediment, produced different secondary metabolites when cultured in 3% and 10% saline conditions. Four characteristic metabolites, only produced in the 10% salinity culture, were isolated, and their structures were identified as (2E,2'Z)-3,3'-(6,6'-dihydroxybiphenyl-3,3'-diyl)diacrylic acid (1), aspulvinone E (2), aspochalasin E (3) and trichodermamide B (6), according to their 1D and 2D NMR spectra. Compound 1 is a new compound. High salt stress may therefore be a promising means to induce the production of new and chlorinated compounds in halotolerant fungi. Compound 1 showed moderate antibacterial activity against Pseudomonas aeruginosa and Escherichia coli with minimum inhibitory concentration (MIC) values of 0.038 and 0.767 mM, respectively. © 2011 by the authors; licensee MDPI.

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Wang, Y., Lu, Z., Sun, K., & Zhu, W. (2011). Effects of high salt stress on secondary metabolite production in the marine-derived fungus Spicaria elegans. Marine Drugs, 9(4), 535–542. https://doi.org/10.3390/md9040535

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