Enantioselective synthesis of alkaloids and carbohydrates via chemoenzymatic methods

Abstract

Homochiral diene diols of type 1, derived biocatalytically by microbial dioxygenation of halogenated aromatic compounds, have served as precursors to a number of oxygenated natural products. Specifically, D-chiro-inositol (9), D-erythuronolactone (10), (+)-lycoricidine (14), (+)-kifunensine (19), and L-threo-sphingosine (25) have all been synthesized from 1. © 1994 IUPAC