Pyridine N-oxide derivatives: Unusual anti-HIV compounds with multiple mechanisms of antiviral action

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Abstract

Pyridine N-oxide derivatives represent a new class of anti-HIV compounds, for which some members exclusively act through inhibition of HIV-1 reverse transcriptase and thus characteristically behave as non-nucleoside reverse transcriptase inhibitors. Other members act, additionally or alternatively, at a post-integrational event in the replication cycle of HIV, that is, at the level of HIV gene expression. Repeated administration of one of the prototype compounds (JPL-32) to DBA/2 and hu-PBMC-SCID mice demonstrated, in the absence of any acute toxicity, protective activity against HIV-induced destruction of CD4 human T lymphocytes. © The British Society for Antimicrobial Chemotherapy 2005; all rights reserved.

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Balzarini, J., Stevens, M., De Clercq, E., Schols, D., & Pannecouque, C. (2005). Pyridine N-oxide derivatives: Unusual anti-HIV compounds with multiple mechanisms of antiviral action. Journal of Antimicrobial Chemotherapy, 55(2), 135–138. https://doi.org/10.1093/jac/dkh530

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