A series of experiments was performed to investigate the effects of corticotropin-releasing factor (CRF) on the amplitude of the acoustic startle response (ASR) in rats. Intracerebroventricular (ICV) administration of 1 μg rat CRF significantly potentiated acoustic startle amplitude; these effects were reversed in a dose-dependent manner by pretreatment with the benzodiazepine chlordiazepoxide (CDP). Doses of CDP that anatgonized CRF-potentiated ASR did not lower startle baseline or antagonize amphetamine-or strychnine-potentiated ASR. These results suggest that CRF has "anxiogenic" properties and may serve as a neuroendocrine modulator of stress-enhanced behaviors. © 1986 Springer-Verlag.
CITATION STYLE
Swerdlow, N. R., Geyer, M. A., Vale, W. W., & Koob, G. F. (1986). Corticotropin-releasing factor potentiates acoustic startle in rats: Blockade by chlordiazepoxide. Psychopharmacology, 88(2), 147–152. https://doi.org/10.1007/BF00652231
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