Asymmetric total synthesis of eicosanoid

Abstract

An asymmetric total synthesis of eicosanoid 4 starting from 2,2-dimethyl-(R)-1,3-dioxolane-4-carbaldehyde is described. The key steps involved for the synthesis include modified Simmons-Smith cyclopropanation, stereoselective reduction, ring-closing metathesis (RCM) and Nozaki-Hiyama-Kishi coupling reaction. © ARKAT.