Association of aldosterone synthase (CYP11B2) -344 T/C polymorphism with diabetic nephropathy: A meta-analysis

Abstract

Introduction: Studies on the relation between aldosterone synthase -344 T/C polymorphism and diabetic nephropathy showed controversial conclusions. This meta-analysis aimed to systematically summarize the association between aldosterone synthase (CYP11B2) gene polymorphism and diabetic nephropathy risk. Methods: Embase, PubMed, ScienceDirect, Web of Science, Wanfang Data, VIP Database, China Knowledge Resource Integrated Database and SinoMed have been searched. A total of five studies including 825 cases and 910 controls were included. Results: In overall analysis, significant increased risk was found in recessive comparison (OR = 1.27, 95% CI 1.05-1.55), homozygote comparison (OR = 1.39, 95% CI 1.04-1.88) and allele comparison (OR = 1.20, 95% CI = 1.05-1.39). No significant association was detected in dominant comparison (OR = 1.27, 95% CI 0.97-1.66) and heterozygote comparison (OR = 1.17, 95% CI 0.88-1.56). In subgroup analysis, significant increased risk existed in Asian population in allele comparison (OR = 1.45, 95% CI = 1.17-1.79), dominant comparison (OR = 1.78, 95% CI 1.11-2.87), homozygote comparison (OR = 2.11, 95% CI 1.29-3.47), recessive comparison (OR = 1.54, 95% CI 1.17-2.03), except for heterozygote comparison (OR = 1.44, 95% CI 0.87-2.38). Conclusions: Our meta-analysis indicates that aldosterone synthase (CYP11B2) gene polymorphism may contribute to diabetic nephropathy development, especially in Asian group, with the T allele acting as a risk factor.