Glioblastoma is the most frequent and aggressive primary brain cancer. In preclinical studies, Zika virus, a flavivirus that triggers the death of glioblastoma stem-like cells. However, the flavivirus oncolytic activity has not been demonstrated in human patients. Here we report a glioblastoma patient who received the standard of care therapy, including surgical resection, radiotherapy and temozolomide. However, shortly after the tumor mass resection, the patient was clinically diagnosed with a typical arbovirus-like infection, during a Zika virus outbreak in Brazil. Following the infection resolution, the glioblastoma regressed, and no recurrence was observed. This clinical response continues 6 years after the glioblastoma initial diagnosis.
CITATION STYLE
Garcez, P. P., Guasti, A., Ventura, N., Higa, L. M., Andreiuolo, F., de Freitas, G. P. A., … Niemeyer, P. (2023). Case report: Regression of Glioblastoma after flavivirus infection. Frontiers in Medicine, 10. https://doi.org/10.3389/fmed.2023.1192070
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