Analytical interferences in point-of-care testing glucometers by icodextrin and its metabolites: An overview

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Abstract

Current point-of-care testing (POCT) glucometers are based on various test principles. Two major method groups dominate the market: glucose oxidase-based systems and glucose dehydrogenase-based systems using pyrroloquinoline quinone (GDH-PQQ) as a cofactor. The GDH-PQQ-based glucometers are replacing the older glucose oxidase-based systems because of their lower sensitivity for oxygen. On the other hand, the GDH-PQQ test method results in falsely elevated blood glucose levels in peritoneal dialysis patients receiving solutions containing icodextrin (e.g., Extraneal; Baxter, Brussels, Belgium). Icodextrin is metabolized in the systemic circulation into different glucose polymers, but mainly maltose, which interferes with the GDH-PQQ-based method. Clinicians should be aware of this analytical interference. The POCT glucometers based on the GDH-PQQ method should preferably not be used in this high-risk population and POCT glucose results inconsistent with clinical suspicion of hypoglycemic coma should be retested with another testing system. Copyright © 2009 International Society for Peritoneal Dialysis.

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Floré, K. M. J., & Delanghe, J. R. (2009). Analytical interferences in point-of-care testing glucometers by icodextrin and its metabolites: An overview. Peritoneal Dialysis International. Multimed Inc. https://doi.org/10.1177/089686080902900403

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