Glutathione peroxidase protein. Absence in selenium deficiency states and correlation with enzymatic activity

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Abstract

Glutathione peroxidase (GSHPx) activity is an indicator of selenium status in selenium-deficient individuals. Utilizing polyclonal monospecific antibodies to purified erythrocyte GSHPx, we were able to determine the relationship between enzymatic activity and protein content. In erythrocytes from a selenium- deficient individual who was treated with selenium, and in HL-60 cells grown in the absence of selenium and then returned to selenium-containing medium, there was a direct relationship between enzymatic activity and protein content. Thus, selenium deficiency results not only in a decrease of GSHPx activity, but also in a decrease of GSHPx protein.

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Takahashi, K., Newburger, P. E., & Cohen, H. J. (1986). Glutathione peroxidase protein. Absence in selenium deficiency states and correlation with enzymatic activity. Journal of Clinical Investigation, 77(4), 1402–1404. https://doi.org/10.1172/JCI112449

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