Prognostic Significance of Silent Myocardial Infarction in Newly Diagnosed Type 2 Diabetes Mellitus

Abstract

The UK Prospective Diabetes Study (UKPDS) 9 affords the opportunity to assess the prognostic importance of SMI in newly diagnosed T2DM patients without significant comor-bidities who were followed up over a longer period than in other studies. We have examined the prevalence of SMI in UKPDS participants at enrollment, its correlates, and its rela-tionship with subsequent clinically evident MI and death. Methods Patients Full details of UKPDS participants have been published. 10 Briefly, 5102 of 7616 people referred by their general practitioners with newly diagnosed T2DM were enrolled. Exclusion criteria included severe vascular disease, MI or stroke within the previous year, and major systemic illness. The study received ethical committee ap-proval in each of the 23 UK clinical centers and conformed to the Declaration of Helsinki guidelines. All patients gave informed con-sent before participation.