Towards Optimization of PCR Protocol in DNA Computing

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Abstract

Recently, in the research field of DNA Computing, the improvement of reliability of computation has been expected. Since DNA Computing consists of some chemical reactions, it seems to be clearly important to optimize each reaction protocol in order to improve the reliability of computing. Moreover, the purpose of the reaction in DNA Computing crosses variably. We consider that the optimization of reaction protocol according to each purpose will be necessary. We try to derive positive impact factors on the reaction result from actual experiments by using DOE. From the results of experiments, we show the importance and necessity of optimizing reaction protocol according to each desired reaction.

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Kashiwamura, S., Nakatsugawa, M., Yamamoto, M., Shiba, T., & Ohuchi, A. (2002). Towards Optimization of PCR Protocol in DNA Computing. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 2340, pp. 14–22). Springer Verlag. https://doi.org/10.1007/3-540-48017-x_2

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