Microwave-assisted synthesis of some novel azoles and azolopyrimidines as antimicrobial agents

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Abstract

In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation. Their pharmacological activity toward bacteria and fungi inhibition was screened and compared to the references Chloramphenicol and Trimethoprim/sulphamethoxazole. The antimicrobial results of the investigated compounds revealed promising results and some derivatives have activities similar to the references used.

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Gomha, S. M., Farghaly, T. A., Mabkhot, Y. N., Zayed, M. E. M., & Mohamed, A. M. G. (2017). Microwave-assisted synthesis of some novel azoles and azolopyrimidines as antimicrobial agents. Molecules, 22(3). https://doi.org/10.3390/molecules22030346

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