Combination with hyperthermia and chemotherapy: Liver cancer

Abstract

In liver cancer, there are two kinds of liver cancer. One is a primary hepatocellular carcinoma and the other is metastatic liver cancer. As for the out-of case of a surgery indication of these cancers, administrations into the hepatic artery of an anticancer agent, an arterial-embolism treatment (TACE), RFA, transient embolization by Degradable Starch Microspheres with anticancer agent or systemic chemotherapy are performed. At present, liver resection and transplantation can improve the survival rate of HCC, but long waiting time due to the shortage of donor organs may result in tumor progression. Given these limitations, many nonsurgical methods have been proposed. However, in each monotherapy of these, the curative effect is restrictive and a multidisciplinary treatment is needed. In these cases, the combined effect of hyperthermia is very high.