Anti diarrhea effect of ethanol extract kecapi bark (Sandoricum Koetjape Merr) on male Guinea pig induced with castor oil and bacteria Escherichia coli

Abstract

Objective: Kecapi bark (Sandoricum koetjape Merr.) is a plant of the Meliaceae family that is often used by people to treat diarrhea and abdominal pain. This study aims to determine the effects of antidiarrheal from the ethanol extract of the Kecapi stem bark on induced with castor oil and bacteria Escherichia coli. Methods: Before the in vivo on male guinea pig test was switched first, then 10 ml of castor oil was induced and 7.7 ml of E. coli male guinea pig was induced, then each male guinea was given a variation of dose ethanol extract kecapi stem bark and loperamide as the comparison. Parameters measured in this study were the start time of diarrhea, consistency of feces, frequency, and duration of diarrhea. Result: The results obtained showed that ethanol extract of kecapi bark antidiarrheal effect on guinea pigs induced castor oil (dose of 800 mg/kg body weight) and E. coli. Conclusion: Ethanol extract of Kecapi bark has an activity of antidiarrheal.