Cooperativity arising from local interactions in equilibrium receptor systems provides gain, but does not increase sensory performance, as measured by the signal-to-noise ratio (SNR) due to a fundamental tradeoff between gain and intrinsic noise. Here we allow sensing to be a nonequilibrium process and show that energy dissipation cannot circumvent the fundamental tradeoff, so that the SNR is still optimal for independent receptors. For systems requiring high gain, nonequilibrium 2D-coupled receptors maximize the SNR, revealing a new design principle for biological sensors. © 2013 American Physical Society.
CITATION STYLE
Skoge, M., Naqvi, S., Meir, Y., & Wingreen, N. S. (2013). Chemical sensing by nonequilibrium cooperative receptors. Physical Review Letters, 110(24). https://doi.org/10.1103/PhysRevLett.110.248102
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