Identification and roles of zebrafish histamine receptors

Abstract

Zebrafish, a small vertebrate model organism, has become a widely used tool in neuroscience. We describe the methods for genome modification and translation inhibition to produce new models. The brain histaminergic system comprises neurons in the hypothalamus and histamine receptors hrh1-hrh3, which are concentrated in specific brain regions. Their roles can be studied with several quantitative individual and social behavioral methods.