The role of capsid in hiv-1 nuclear entry

17Citations
Citations of this article
53Readers
Mendeley users who have this article in their library.

Abstract

HIV-1 can infect non-dividing cells. The nuclear envelope therefore represents a barrier that HIV-1 must traverse in order to gain access to the host cell chromatin for integration. Hence, nuclear entry is a critical step in the early stages of HIV-1 replication. Following membrane fusion, the viral capsid (CA) lattice, which forms the outer face of the retroviral core, makes numerous interactions with cellular proteins that orchestrate the progress of HIV-1 through the replication cycle. The ability of CA to interact with nuclear pore proteins and other host factors around the nuclear pore determines whether nuclear entry occurs. Uncoating, the process by which the CA lattice opens and/or disassembles, is another critical step that must occur prior to integration. Both early and delayed uncoating have detrimental effects on viral infectivity. How uncoating relates to nuclear entry is currently hotly debated. Recent technological advances have led to intense discussions about the timing, location, and requirements for uncoating and have prompted the field to consider alternative uncoating scenarios that presently focus on uncoating at the nuclear pore and within the nuclear compartment. This review describes recent advances in the study of HIV-1 nuclear entry, outlines the interactions of the retroviral CA protein, and discusses the challenges of investigating HIV-1 uncoating.

References Powered by Scopus

The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys

1583Citations
N/AReaders
Get full text

Identification of host proteins required for HIV infection through a functional genomic screen

1239Citations
N/AReaders
Get full text

Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication

830Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Nuclear Capsid Uncoating and Reverse Transcription of HIV-1

49Citations
N/AReaders
Get full text

HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration

27Citations
N/AReaders
Get full text

Nuclear entry and egress of parvoviruses

12Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Guedán, A., Caroe, E. R., Barr, G. C. R., & Bishop, K. N. (2021, August 1). The role of capsid in hiv-1 nuclear entry. Viruses. MDPI AG. https://doi.org/10.3390/v13081425

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 14

64%

Researcher 4

18%

Professor / Associate Prof. 3

14%

Lecturer / Post doc 1

5%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 15

65%

Engineering 3

13%

Agricultural and Biological Sciences 3

13%

Medicine and Dentistry 2

9%

Article Metrics

Tooltip
Mentions
Blog Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free