Relationship of the vitamin D receptor and collagen Iα1 gene polymorphisms with low bone mineral density and vertebral fractures in postmenopausal Turkish women

Abstract

Objectives: This study aims to investigate (i) the frequencies of the vitamin D receptor (VDR) gene and collagen Ia1 (COL Ia1) gene polymorphisms and (ii) whether there is a relation between the Bsm1 polymorphisms in the VDR gene, and the Sp1 polymorphisms in the COL Ia1 gene and low bone mineral density (BMD), and vertebral fractures in postmenopausal Turkish women. Patients and methods: A hundred postmenopausal Turkish women (mean age 63.4±8.7 years; range 48 to 86 years) who were admitted to our polyclinic for the diagnosis or treatment of osteoporosis were included in this study. The study population was divided into three groups according to the T score value based on BMD measurements. Patients with a T score of >-1.0 formed the control group (n=30). In addition, patients with a T score of -2.5 formed the osteopenic group (n=30), and those with a T score of