Effect of Feeding Clofibrate-Containing Diet on the Hepatic NAD+ Level in Rats

Abstract

Feeding rats with a diet containing 0.25% Clofibrate for 2 weeks elevated the hepatic NAD+ and total nicotinate levels significantly. Other peroxisome proliferators, such as 2-(4-chlorophenoxy)propionic acid and di (2-ethylhexyl)phthalate, had similar effects. When rats were fed the control diet without Clofibrate for 1 week after 2 weeks of the Clofibrate diet, the hepatic NAD+ level returned to the control value. Muscular NAD+ content was not affected by the peroxisome proliferators. The results were discussed in relation to induction of peroxisomal β-oxidation enzymes by the peroxisome proliferators. © 1995, Center for Academic Publications Japan. All rights reserved.