Structure and cytotoxicity of novel lignans and lignan glycosides from the aerial parts of larrea tridentata

5Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

Abstract

Previously, the authors conducted phytochemical investigations of the aerial parts of Larrea tridentata and reported triterpene glycosides and lignan derivatives. In continuation of the preceding studies, 17 lignans and lignan glycosides (1–17) were isolated, including seven new compounds (1–7). Herein, the structure of the new compounds was determined based on spectroscopic analysis and enzymatic hydrolysis. The cytotoxicity of 1–17 against HL-60 human promyelocytic leukemia cells was examined. Compounds 4–11 and 14–16 were cytotoxic to HL-60 cells, with IC50 values in the range of 2.7–17 µM. Compound 6, which was the most cytotoxic among the unprecedented compounds, was shown to induce apoptotic cell death in HL-60 cells.

Cite

CITATION STYLE

APA

Yokosuka, A., Iguchi, T., Jitsuno, M., & Mimaki, Y. (2021). Structure and cytotoxicity of novel lignans and lignan glycosides from the aerial parts of larrea tridentata. Molecules, 26(20). https://doi.org/10.3390/molecules26206186

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free