Inhibitory effect of oolong tea on the oxidative state of low density lipoprotein (LDL)

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Abstract

In the present study, we investigated the anti-oxidant activity of oolong tea in an oxidation model using human low-density lipoprotein (LDL). Oolong tea suppressed the oxidation of LDL induced by 2-2′-azobis 4-methoxy-2,4-dimethyvaleronitrile (V70) in a dose-dependent manner, that is, it prolonged the lag time to 114.3%, 138% and 199.9% as compared with the control group at 0.5 μg/ml, 1.0 μg/ml, and 2.5 μg/ml, respectively. We also determined the scavenging effect of oolong tea on active oxygen radicals using the electron spin resonance (ESR) technique with 5,5-dimethyl-1-pyrroline N-oxide (DMPO) as a spin trapping agent. The intensity of the ESR signals for the DMPO-OOH adduct formed by the hypoxanthine/xanthine oxidase reaction system with DMPO decreased in the presence of oolong tea. The IC50 of oolong tea was 19.9 μg/ml. These findings suggested that oolong tea has beneficial effects on health related to its anti-oxidative action.

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Kurihara, H., Fukami, H., Toyoda, Y., Kageyama, N., Tsuruoka, N., Shibata, H., … Tanaka, T. (2003). Inhibitory effect of oolong tea on the oxidative state of low density lipoprotein (LDL). Biological and Pharmaceutical Bulletin, 26(5), 739–742. https://doi.org/10.1248/bpb.26.739

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