A recent Cell publication demonstrates that the secreted antagonist of transforming growth factor-beta ligands, Coco, can re-activate previously dormant metastatic breast cancer cells specifically in the lung by inhibiting bone morphogenetic protein (BMP) signaling. The authors provided evidence for a connection between Coco/BMP signaling and molecular and cellular traits of cancer stem cells. Their findings represent a significant advance in our understanding of metastatic dormancy, an extremely important clinical issue that remains understudied. Equally as important, this study also opens interesting avenues for future research. © 2013 BioMed Central Ltd.
CITATION STYLE
Martinez, J., & Zhang, X. H. F. (2013). BMP/Coco antagonism as a deterministic factor of metastasis dormancy in lung. Breast Cancer Research, 15(1). https://doi.org/10.1186/bcr3350
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