Modelling molecular processes by individual-based simulations applied to actin polymerisation

Abstract

Used in ecology, economics and social science, agent-based modelling is also increasingly used in the life science. We use this technique to model and simulate the processing of actin filaments. These filaments form a major part of the cell-shape determining cytoskeleton and contribute to a number of cell functions. In our paper, we develop and investigate three models with different levels of detail. Our work demonstrates the potential of individual-based modelling in systems biology.