Imatinib Mesylate Inhibits Antigen-Specific Memory CD8 T Cell Responses In Vivo

  • Sinai P
  • Berg R
  • Haynie J
  • et al.
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Abstract

Imatinib mesylate (IM) is effective at inducing complete cytogenetic remission in patients with chronic myelogenous leukemia. Because its influence on CD8 T cell responsiveness in vivo is unknown, we investigated the effects of IM by analyzing the response of OT-1 CD8 T cells to Listeria monocytogenes (LM) that express the cognate epitope OVA257–264 (LM-OVA). In vitro, IM had no effect on Ag-specific expansion, cell division, cell cycle progression, or IFN-γ expression in naive or memory OT-1 T cells. However, IM induced apoptosis of naive and memory OT-1 T cells at doses of >5 μM. At 15 μM IM, OT-1 T cells did not survive in in vitro cultures. The primary response of OT-1 T cells in vivo to LM-OVA infection was unaltered. In contrast, continuous IM treatment resulted in a diminished memory OT-1 response. The expression of IL-7Rα, a receptor required for memory cell survival, was lower (on OT-1 cells) in animals receiving IM. These results indicate that IM treatment affects the ability of the CD8 memory pool to respond to Ag and has the potential to increase susceptibility to infection.

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APA

Sinai, P., Berg, R. E., Haynie, J. M., Egorin, M. J., Ilaria, R. L., & Forman, J. (2007). Imatinib Mesylate Inhibits Antigen-Specific Memory CD8 T Cell Responses In Vivo. The Journal of Immunology, 178(4), 2028–2037. https://doi.org/10.4049/jimmunol.178.4.2028

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