A systematic review and meta-analysis of the association between sarcopenia and myocardial infarction

Abstract

Background: Systematic review and meta-analysis of the association between sarcopenia and the development of myocardial infarction. Methods: PubMed, Cochrane Library, and Embase were searched for studies on the association between sarcopenia and myocardial infarction from their inception until November 26, 2022. The fixed-effects model was used to calculate the combined risk ratio (RR) of sarcopenia in patients with myocardial infarction. Sensitivity analysis was used to test the robust of the combined result, and funnel plot were used to test publication bias. Results: Five studies were included finally. There was no significant association between sarcopenia and risk of developing myocardial infarction [RR = 1.01; 95% CI = 0.94, 1.08; P = 0.317]. The sensitivity analysis showed robust of the combined result. The funnel plot showed no significant publication bias. Conclusion: Limited evidence suggests no definitive association between sarcopenia and risk of myocardial infarction.