Gremlin is a member of the TGF-β superfamily that can act as a BMP antagonist, and recently, has been described as a ligand of the vascular endothelial growth factor receptor 2 (VEGFR2). Gremlin shares properties with the Notch signaling pathway. Both participate in embryonic development and are reactivated in pathological conditions. Gremlin is emerging as a potential therapeutic target and biomarker of renal diseases. Here we review the role of the Gremlin–VEGFR2 axis in renal damage and downstream signaling mechanisms, such as Notch pathway.
CITATION STYLE
Marquez-Exposito, L., Cantero-Navarro, E., R. Rodrigues-Diez, R., Orejudo, M., Tejera-Muñoz, A., Tejedor, L., … Ruiz-Ortega, M. (2020). Molecular Regulation of Notch Signaling by Gremlin. In Advances in Experimental Medicine and Biology (Vol. 1227, pp. 81–94). Springer. https://doi.org/10.1007/978-3-030-36422-9_6
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