Silica-supported boric acid with ionic liquid: A novel recyclable catalytic system for one-pot three-component mannich reaction

Abstract

A rapid and efficient silica-supported boric acid/ionic liquid ([β-mim][PF6]), catalyzed, one-pot three-component Mannich reaction has been carried out to synthesize b-amino carbonyl compounds at room temperature. The reaction afforded desired products in excellent yields with moderate to good diastereoselectivity. The method provides a novel modification of three-component Mannich reaction in terms of mild reaction conditions, clean reaction profiles, low amount of catalyst, recyclability of catalyst and a simple workup procedure. The present report first time describes the preparation of H3BO3-SiO2 catalyst and its use with [bmim][PF6], to synthesize Mannich products. The catalyst can be reused at least seven times. © 2011 Pharmaceutical Society of Japan.