Turbidimetric D-Dimer Test in the Diagnosis of Pulmonary Embolism: A Metaanalysis

66Citations
Citations of this article
35Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Background: Clinicians in outpatient clinics and emergency departments desire an accurate quantitative D-dimer assay. The study objective was to evaluate the diagnostic performance characteristics of the latex turbidimetric D-dimer test in the diagnosis of pulmonary embolism (PE) in the emergency department population. Methods: We conducted a search of MEDLINE, EMBASE, and bibliographies of previous systematic reviews with no language restriction. Experts in the field of PE research were contacted to identify unpublished studies. Prospective investigations involving predominately outpatient populations with suspected PE that used a turbidimetric D-dimer test were included. Two authors extracted data independently and assessed study quality based on the composition of the patient spectrum and the reference standard used. Consensus was reached by conference. The analysis was based on a summary ROC curve and combining sensitivity and specificity independently across studies using a random-effects model. Results: The search yielded 264 publications and 2 unpublished studies. Nine studies met the inclusion criteria and provided a sample of 1901 individuals. Eight of the nine studies were homogeneous in terms of both sensitivity and specificity. One study had similar sensitivity but higher specificity. Combining the studies yielded an overall sensitivity of 0.93 (95% confidence interval, 0.89-0.96) and an overall specificity of 0.51 (95% confidence interval, 0.42-0.59). Conclusions: The turbidimetric D-dimer test is sensitive but nonspecific for the detection of PE in the emergency department setting. D-Dimer tests using latex turbidimetric methods appear to have test characteristics comparable to those for ELISA methods. © 2003 American Association for Clinical Chemistry.

References Powered by Scopus

32401Citations
4615Readers

This article is free to access.

This article is free to access.

Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Brown, M. D., Lau, J., Nelson, R. D., & Kline, J. A. (2003). Turbidimetric D-Dimer Test in the Diagnosis of Pulmonary Embolism: A Metaanalysis. Clinical Chemistry, 49(11), 1846–1853. https://doi.org/10.1373/clinchem.2003.022277

Readers over time

‘10‘12‘13‘14‘15‘16‘17‘18‘19‘20‘21‘23‘2402468

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 10

71%

Researcher 3

21%

Professor / Associate Prof. 1

7%

Readers' Discipline

Tooltip

Medicine and Dentistry 15

68%

Biochemistry, Genetics and Molecular Bi... 4

18%

Agricultural and Biological Sciences 2

9%

Materials Science 1

5%

Save time finding and organizing research with Mendeley

Sign up for free
0