Caffeic acid oligomers with hyaluronidase inhibitory activity from Clinopodium gracile

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Abstract

Eight new caffeic acid oligomers, clinopodic acids J-Q (1-8), were isolated from whole plants of Clinopodium gracile, together with nine known caffeic acid oligomers. The caffeic acid oligomers with two to four dihydrobenzofuran rings were isolated as natural products for the first time. Clinopodic acid M (4) showed the strongest hyaluronidase inhibitory activity, IC 50 (19 μM) among the 22 compounds isolated from this plant. © 2012 The Pharmaceutical Society of Japan.

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Aoshima, H., Miyase, T., & Warashina, T. (2012). Caffeic acid oligomers with hyaluronidase inhibitory activity from Clinopodium gracile. Chemical and Pharmaceutical Bulletin, 60(4), 499–507. https://doi.org/10.1248/cpb.60.499

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