Machine learning methods have of late made significant efforts to solving multidisciplinary problems in the field of cancer classification in microarray gene expression data. These tasks are characterized by a large number of features and a few observations, making the modeling a nontrivial undertaking. In this study, we apply entropic filter methods for gene selection, in combination with several off-the-shelf classifiers. The introduction of bootstrap resampling techniques permits the achievement of more stable performance estimates. Our findings show that the proposed methodology permits a drastic reduction in dimension, offering attractive solutions in terms of both prediction accuracy and number of explanatory genes; a dimensionality reduction technique preserving discrimination capabilities is used for visualization of the selected genes. © 2011 Springer Science+Business Media, LLC.
CITATION STYLE
González-Navarro, F. F., & Belanche-Muñoz, L. A. (2011). Parsimonious selection of useful genes in microarray gene expression data. In Advances in Experimental Medicine and Biology (Vol. 696, pp. 45–55). https://doi.org/10.1007/978-1-4419-7046-6_5
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