Comment on “Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells”

Abstract

Thornton et al. ([1][1]) reported recently that in both mouse and man, ∼70% of peripheral Foxp3+ regulatory T cells (Tregs) express the transcription factor Helios. Interestingly, they found that Foxp3+ cells generated in the thymus all coexpressed Helios, whereas Tregs generated in vitro from