Neuroprotective effect of ace inhibitors in glutamate - induced neurotoxicity: Rat neuron culture study

11Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

Aim: Glutamate is known to be neurotoxic at concentrations of 10-6M and 10-7M. Angiotensin converting enzyme (ACE) inhibitors can be assumed to be neuroprotective as they open the mitochondrial adenosine triphosphate-sensitive potassium channels by inhibiting the degradation of bradykinin. In this study, we investigated whether the ACE inhibitors captopril, ramipril and perindopril have protective effects in glutamate-induced neurotoxicity in newborn rat cerebral cortex cell cultures. Ma terial and Methods: Viability tests were performed among ACE inhibitors by constituting groups of control and 10-7M and 10-6M glutamate doses in newborn rat cortex cultures. Results: While the mean viable cell number was 0.47±0.06 in the control group, it was 0.37±0.03 in the group exposed to 10-7M glutamate (p<0.05) and 0.37±0.01 in the group exposed to 10-6M glutamate (p<0.05). Captopril was used at a dose of 10 μM, perindopril was used at a dose of 1 μM, and ramipril was used at a dose of 30 μM against 10-7M and 10-6M glutamate. Ramipril and perindopril reversed the toxicity against 10-6M glutamate (p<0.05). The neuroprotective properties of captopril, perindopril and ramipril were not found to be statistically significant against 10-7M glutamate at the doses mentioned above. Conclusion: Data obtained from this study indicate that ramipril and perindopril can prevent 10-6M glutamate-induced neurotoxicity.

References Powered by Scopus

Reactive oxygen radicals in signaling and damage in the ischemic brain

1501Citations
N/AReaders
Get full text

Glutamate-dependent astrocyte modulation of synaptic transmission between cultured hippocampal neurons

470Citations
N/AReaders
Get full text

Compartmentation of brain glutamate metabolism in neurons and glia

273Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Current status of renin-aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease

52Citations
N/AReaders
Get full text

Is L-glutathione more effective than L-glutamine in preventing enteric diabetic neuropathy?

38Citations
N/AReaders
Get full text

Angiotensin-converting enzyme inhibitors and amyotrophic lateral sclerosis risk: A total population-based case-control study

33Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Sengul, G., Coskun, S., Cakir, M., Coban, M. K., Saruhan, F., & Hacimuftuoglu, A. (2011). Neuroprotective effect of ace inhibitors in glutamate - induced neurotoxicity: Rat neuron culture study. Turkish Neurosurgery, 21(3), 367–371. https://doi.org/10.5137/1019-5149.JTN.4313-11.0

Readers over time

‘12‘15‘17‘18‘19‘20‘21‘22‘23‘2400.511.52

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 3

75%

Professor / Associate Prof. 1

25%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 3

50%

Medicine and Dentistry 1

17%

Pharmacology, Toxicology and Pharmaceut... 1

17%

Immunology and Microbiology 1

17%

Save time finding and organizing research with Mendeley

Sign up for free
0