Background: To investigate the association between the CD14 –159C/T polymorphism and ischemic stroke (IS). Methods: Relevant literature was searched by retrieving EMBASE, Web of Science, Chinese National Knowledge Infrastructure, and PubMed databases. R version 3.33 software was applied to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs). Results: Seven qualified studies with a total of 2058 IS patients and 2123 controls were included. There was no significant association between the CD14 –159C/T polymorphism and IS risk in the total population (TT vs CC: OR = 0.84, 95% CI = 0.58–1.20; CT vs CC: OR = 0.96, 95% CI = 0.82–1.12; dominant model: OR = 1.02, 95% CI = 0.80–1.30; recessive model: OR = 0.82, 95% CI = 0.57–1.19). Similarly, subgroup analysis according to ethnicity and Hardy–Weinberg equilibrium also found no significant interrelation. Conclusion: Our findings suggest that the CD14 –159C/T polymorphism does not contribute to the risk of IS. Well-designed studies with more subjects are required to further validate these results.
Mendeley helps you to discover research relevant for your work.
CITATION STYLE
Xu, M., Wang, L., Sun, L., Li, Z., & Zhang, H. (2019). The CD14 gene –159C/T polymorphism and the risk of ischemic stroke: a meta-analysis. Journal of International Medical Research, 48(3). https://doi.org/10.1177/0300060519886241