The present study was carried out to evaluate the chemical and pharmacological properties of the essential oil of Lavandula stoechas subsp. luisieri, which is a spontaneous shrub widespread in Alentejo (Portugal). Oxygenated monoterpenes, such as 1,8-cineole, lavandulol, and necrodane derivatives, are the main components of essential oil. It revealed important antioxidant activity with a high ability to inhibit lipid peroxidation and showed an outstanding effect against a wide spectrum of microorganisms, such as gram-positive and gram-negative bacteria and pathogenic yeasts. The analgesic effect studied in rats was dose dependent, reaching a maximum of 67% at 60 min with the dose of 200mg/kg and the antiinflammatory activity with this dose caused an inhibition in carrageenan-induced rat paw oedema (83%) that is higher than dexamethasone 1mg/Kg (69%). Besides, animals exhibited normal behaviour after essential oil administration, revealing low toxicity. The essential oil of L. luisieri from Alentejo presents important pharmacological properties and low toxicity, and is a promised candidate to be used as a food supplement or in pharmaceutical applications.
CITATION STYLE
Arantes, S., Candeias, F., Lopes, O., Lima, M., Pereira, M., Tinoco, T., … Martins, M. R. (2016). Pharmacological and toxicological studies of essential oil of Lavandula stoechas subsp. Luisieri. Planta Medica, 82(14), 1266–1273. https://doi.org/10.1055/s-0042-104418
Mendeley helps you to discover research relevant for your work.