Evaluation of the use of tranexamic acid in total knee arthroplasty

Abstract

r e v b r a s o r t o p. 2 0 1 8;5 3(6):761-767 SOCIEDADE BRASILEIRA DE ORTOPEDIA E TRAUMATOLOGIA w w w. r b o. o r g. b r Orthopedic Total knee arthroplasty Blood transfusion Blood volume a b s t r a c t Objective: Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty. Methods: 101 patients were randomized into two groups: the tranexamic acid group (n = 51) and the placebo group (n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate. Results: Comparing the groups, there were statistically significant differences (p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion. Conclusion: The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty. © 2017 Sociedade Brasileira de Ortopedia e Traumatologia. Published by Elsevier Editora Ltda. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). Avaliação do uso do ácido tranexâmico em artroplastia total do joelho Palavras-chave: Ácido tranexâmico Sangramento Ortopedia Artroplastia do joelho Transfusão de sangue Volume sanguíneo r e s u m o Objetivo: Avaliar a eficácia do ácido tranexâmico na redução do sangramento em pacientes submetidos a artroplastia total de joelho. Métodos: Foram randomizados 101 pacientes em dois grupos: grupo ácido tranexâmico (n = 51) e grupo placebo (n = 50). Os pacientes foram comparados nos quesitos redução da hemoglobina, perda sanguínea total estimada, débito do dreno e taxa de hemotransfusão pós-operatória.