In the germinal center (GC), follicular helper T (TFH) cells interact with B cells and undergo a series of GC reactions to ultimately produce high-affinity antibodies and memory plasma cells. Recent studies have found a subpopulation of regulatory T cells called follicular regulatory T (TFR) cells. TFR cells can inhibit TFH cells and/or B cells in a variety of ways to specifically regulate GC reactions. Dysfunction of TFR cells may lead to immune disorders and a variety of autoimmune diseases. In this review, we summarize the differentiation and function of TFR cells and provide an overview of TFR cells in autoimmune diseases.
CITATION STYLE
Gong, Y., Tong, J., & Wang, S. (2017, December 11). Are follicular regulatory T cells involved in autoimmune diseases? Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2017.01790
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