Singlet oxygen (1O2), generated by irradiating methylene blue, is toxic to melanoma cell cultures. Hypotaurine is known to scavenge efficiently singlet oxygen; the addition of hypotaurine (800 μM) to the medium during irradiation of the dye produces a greater protective effect on cells than taurine added at the same concentration. The assay of some detoxifying enzymatic activities indicate a different mechanism of protection of the two molecules: taurine induces an efficient detoxifying enzymatic action with respect to the control; hypotaurine exerts its effect greatly by specifically scavenging singlet oxygen.
CITATION STYLE
Pitari, G., Duprè, S., Spirito, A., Antonini, G., & Amicarelli, F. (2000). Hypotaurine protection on cell damage by singlet oxygen. Advances in Experimental Medicine and Biology, 483, 157–162. https://doi.org/10.1007/0-306-46838-7_16
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