La epigenética en la diabetes mellitus tipo 2: una enfermedad crónica no transmisible

Abstract

Type 2 diabetes mellitus continues to be a pandemic without apparent solution. Studies performed in the last couple of decades have found an important relationship between epigenetics and type 2 diabetes mellitus, determining that the environment in which an individual develops, even during the prenatal stage has an important influence in the future development of diverse pathologies. DNA methylation, histone modification and non-coding RNA's are the main regulators of epigenetics. In contrast to the genome, the epigenome is potentially reversible and may be corrected through different interventions that could modify the course of this disease. Despite of this, epigenetics present certain limitations that delay its study; along with genetics, proteomics and metabolomics, epigenetic is one more alternative for the identification of biomarkers that may allow a prediction for the development of type 2 diabetes mellitus., La diabetes mellitus tipo 2 continúa siendo una pandemia sin aparen.