Abstract
Nimesulide (NI), a non steroidal anti-inflammatory drug, is very poorly soluble in water. The aim of this work is to study the in vitro and in vivo characteristics of a NI Na-j3-cyclodextrin (CD) complex in the stoichiometric ratio 1: 1. The complex was prepared by spray-drying and the inclusion could be demonstrated by DSC and solubility method. This study has shown that the NI Na-j3-CD complex can increase the aqueous solubility ofNI (about 5000 times) as well as the solubility in acidic medium (7 times) and at pH 6.8 (34 times). A preliminary study in 3 healthy volunteers has shown promising results for further galenic developments.
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CITATION STYLE
Peel, G., Delneuville, I., & Delattre, L. (1996). In Vitro and in Vivo Studies on Sodium Nimesulide-β-Cyclodextrin Inclusion Complex. In Proceedings of the Eighth International Symposium on Cyclodextrins (pp. 487–490). Springer Netherlands. https://doi.org/10.1007/978-94-011-5448-2_107
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