Observational studies classically find an inverse relationship between human plasma 25hydroxyvitamin D concentration and obesity. However, interventional and genetic studies have failed to provide clear conclusions on the causal effect of vitamin D on obesity/adiposity. Likewise, vitamin D supplementation in obese rodents has mostly failed to improve obesity parameters, whereas several lines of evidence in rodents and prospective studies in humans point to a preventive effect of vitamin D supplementation on the onset of obesity. Recent studies investigating the impact of maternal vitamin D deficiency in women and in rodent models on adipose tissue biology programming in offspring further support a preventive metabolically driven effect of vitamin D sufficiency. The aim of this review is to summarize the state of the knowledge on the relationship between vitamin D and obesity/adiposity in humans and in rodents and the impact of maternal vitamin D deficiency on the metabolic trajectory of the offspring.
CITATION STYLE
Bennour, I., Haroun, N., Sicard, F., Mounien, L., & Landrier, J. F. (2022, May 1). Vitamin D and Obesity/Adiposity—A Brief Overview of Recent Studies. Nutrients. MDPI. https://doi.org/10.3390/nu14102049
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