Renal Clearance of N-Terminal pro-Brain Natriuretic Peptide Is Markedly Decreased in Chronic Kidney Disease

  • Tsutamoto T
  • Sakai H
  • Yamamoto T
  • et al.
N/ACitations
Citations of this article
16Readers
Mendeley users who have this article in their library.

Abstract

Background: The ratio of N-terminal pro-brain natriuretic peptide (NT-proBNP) secretion from the heart to peripheral NT-proBNP remains unknown in patients with chronic kidney disease (CKD). Methods and Results: We measured plasma NT-proBNP in the aortic root (AO; NT-proBNP(AO)) and in the coronary sinus (CS; NT-proBNP(CS)) in 544 patients. Patients were classified into 6 categories based on estimated glomerular filtration rate (eGFR): G1, n=44, eGFR ≥90 mL/min/1.73 m(2); G2, n=221, 60≤eGFR<90 mL/min/1.73 m(2); G3a, n=132, 45≤eGFR<60 mL/min/1.73 m(2); G3b, n=77, 30≤eGFR<45 mL/min/1.73 m(2); G4, n=34, 15≤eGFR<30 mL/min/1.73 m(2); and G5, n=36, eGFR <15 mL/min/1.73 m(2). In non-CKD patients, hemodynamics but not eGFR were independent predictors of log NT-proBNP. In CKD patients, eGFR and hemodynamics were independent predictors of log NT-proBNP. The ratio of NT-proBNP secretion from the heart to NT-proBNP(AO) significantly decreased with decreasing eGFR in 6 groups (P<0.0001): G1, 67±38%; G2, 50±24%; G3a, 40±21%; G3b, 30±16%; G4, 14.8±7.9%; and G5, 3.5±2.4%, respectively. Conclusions: eGFR contributes to the value of NT-proBNP for prediction of hemodynamic overload in CKD patients but not in non-CKD patients, and the ratio of NT-proBNP secretion from the heart to peripheral NT-proBNP is markedly decreased in CKD patients, especially those with eGFR <30 mL/min/1.73 m(2).

Cite

CITATION STYLE

APA

Tsutamoto, T., Sakai, H., Yamamoto, T., & Nakagawa, Y. (2019). Renal Clearance of N-Terminal pro-Brain Natriuretic Peptide Is Markedly Decreased in Chronic Kidney Disease. Circulation Reports, 1(8), 326–332. https://doi.org/10.1253/circrep.cr-19-0063

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free