Effect of Aqueous Extract of Phaseolus Vulgaris on the Regulation of Glucose and Lipid Metabolism in Diabetic Rats

Abstract

The objective of this work was to evaluate the hypoglycemic and lipid-lowering effect of the aqueous extract of Phaseolus vulgaris in rat rendered diabetic by diet. The effects of the nutritional supplementation of Phaseolus vulgaris, at the rates of 300 mg / Kg in high carbohydrate and high fat diets, diabetic Wistar rat race, for 6 weeks, were analyzed on several measures of glucose and lipid metabolism. The aqueous extract of bean seed germinated is highly effective in reducing the level of glucose in the blood of diabetic rats, while increasing insulin levels. The concurrent negative biochemical factors in the type 2 diabetes, such as triglycerides, total cholesterol, and LDL cholesterol undergo a decrease, while the HDL cholesterol increased in diabetic rats having ingested the aqueous extract of bean seed. Thus, Phaseolus vulgaris is an important contribution in the formulation of dietetic diets, because it constitutes a useful supplement which would permit to decrease the dosages of oral hypoglycemic in the case of the non insulino-dependent diabetes, by giving a greater comfort of life to the patient, and by decreasing the importance of the side effects related to the anti-diabetic medications which are far from being negligible.