In Vitro and In Vivo Evaluation of Oxatomide β -Cyclodextrin Inclusion Complex

Abstract

The objective of this study was to evaluate the influence of oxatomide β -cyclodextrin inclusion complex on the physicochemical properties and bioavailability of the drug. Oxatomide β -cyclodextrin solid complex was prepared with equimolar ratio of both oxatomide and β -cyclodextrin in presence or absence of water soluble polymers using different techniques. The coevaporated complex prepared in presence of PVP-K15 showed a prompt drug release and significantly increased % dissolution efficiency compared to the pure oxatomide. Moreover, the results of bioavailability evaluation of this complex in rabbits compared to commercial drug product indicated a 73.15% increase in the oral bioavailability of oxatomide. In conclusion, inclusion complex of oxatomide with β -cyclodextrin prepared by coevaporation in presence of PVP-K15 not only results in an enhancement of the oxatomide dissolution rate but also improves the bioavailability of oxatomide.