Metastatic liver cancer and microenvironment

Abstract

The metastasis to adjacent locations and distance is one of the most important biological characteristics that distinguish malignant tumors from benign tumors. In 1976, Bross and Blumenson proposed the famous “metastatic cascade theory” [1], i.e., the complicated, dynamic, and continuous biological process of invasion and metastasis can be basically divided into the following relatively independent steps