Isolation, Physicochemical Properties and Biological Activities of Amicoumacins Produced by Bacillus pumilus

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Abstract

Bacillus pumilus BN-103 was found to produce a new antibiotic complex named amicoumacin. The antibiotic was isolated from the culture broth by ion-exchange resin and carbon chromatographies. Amicoumacin A was a major component of the mixture, and exhibited not only antibacterial activity, but also antiinflammatory and antiulcer activities. Amicoumacin B and C showed moderate activity against bacteria, but did not exhibit any pharmacological activity. © 1982, Japan Society for Bioscience, Biotechnology, and Agrochemistry. All rights reserved.

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Itoh, J., Shomura, T., Omoto, S., Miyado, S., Yuda, Y., Shibata, U., & Inouye, S. (1982). Isolation, Physicochemical Properties and Biological Activities of Amicoumacins Produced by Bacillus pumilus. Agricultural and Biological Chemistry, 46(5), 1255–1259. https://doi.org/10.1271/bbb1961.46.1255

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