MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.
CITATION STYLE
Alivernini, S., Gremese, E., McSharry, C., Tolusso, B., Ferraccioli, G., McInnes, I. B., & Kurowska-Stolarska, M. (2018, January 5). MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2017.01932
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