Clinical Trial with Ambilhar in Schistosoma mansoni Infections in Tanzania

Abstract

Ambilhar in a dosage of 25 mg./kg. body weight/day for seven days was given to 92 patients infected with Schistosoma mansoni. The effectiveness of the drug appears to compare favourably with Astiban in a total dose of 30 mg./kg. body weight, particularly when the mean percentage reduction in egg output is used as an index of drug efficiency. Children are more resistant to treatment, and also tolerate the drug better than do adults. Serious drug reactions encountered were epileptiform seizures, psychoses, and epistaxis. Because of these reactions it is recommended that this drug should not be used for mass treatment of adults. © 1966, British Medical Journal Publishing Group. All rights reserved.