Mechanism of action of pimavanserin in Parkinson's disease psychosis: Targeting serotonin 5HT2A and 5HT2C receptors

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Abstract

Pimavanserin, a novel agent approved for the treatment of Parkinson's disease psychosis, has potent actions as an antagonist/inverse agonist at serotonin 5HT2A receptors and less potent antagonist/inverse agonist actions at 5HT2C receptors.

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Stahl, S. M. (2016). Mechanism of action of pimavanserin in Parkinson’s disease psychosis: Targeting serotonin 5HT2A and 5HT2C receptors. CNS Spectrums, 21(4), 271–275. https://doi.org/10.1017/S1092852916000407

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