Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature Review

  • Khurana S
  • Beltran M
  • Jiang L
  • et al.
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Abstract

Cutaneous involvement by precursor T-cell lymphoblastic leukemia/lymphoma (T-ALL/LBL) is rare, and almost all cases are seen in association with bone marrow, blood, and/or lymph node involvement. Presentation with isolated skin involvement is very rare. Literature review revealed only one case report of primary cutaneous T-cell LBL. We discuss here another patient diagnosed with primary cutaneous T-cell LBL at our institute. This patient was initially misdiagnosed as having peripheral T-cell lymphoma NOS. Cytogenetic analysis showed the CDKN2A deletion (−9p21×2) in addition to three intact copies of ABL1 (+9q34). Although she failed multiple lines of intensive chemotherapy, her disease remained confined to the skin. We believe that this presentation of T-LBL is underreported, and many patients are likely misdiagnosed as having high-grade cutaneous T-cell lymphomas. With this case and literature review, we would like to highlight the importance of keeping lymphoblastic lymphoma on the differential diagnosis of cutaneous T-cell lymphoma-like lesions to avoid delay in diagnosis and inappropriate treatment of this aggressive disease.

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Khurana, S., Beltran, M., Jiang, L., Ayala, E., & Roy, V. (2019). Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature Review. Case Reports in Hematology, 2019, 1–6. https://doi.org/10.1155/2019/3540487

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